Annalisa Santucci Selected Research

Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome)

1/2019

Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: Preliminary in vitro studies with analogues of immucillin-G.

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Annalisa Santucci Research Topics

Disease

47	Alkaptonuria 03/2024 - 10/2010
15	Ochronosis 03/2024 - 10/2010
13	Neoplasms (Cancer) 01/2022 - 06/2006
11	Inborn Genetic Diseases (Disease, Hereditary) 01/2023 - 10/2010
10	Infections 01/2021 - 02/2006
10	Amyloidosis 12/2020 - 01/2011
9	Rare Diseases (Rare Disease) 01/2023 - 11/2012
8	Osteosarcoma (Osteogenic Sarcoma) 07/2020 - 06/2006
7	Inflammation (Inflammations) 11/2022 - 12/2016
4	Metabolic Diseases (Metabolic Disease) 12/2022 - 11/2015
3	Hypersensitivity (Allergy) 05/2022 - 11/2010
3	Neoplasm Metastasis (Metastasis) 07/2020 - 01/2018
3	Disease Progression 01/2020 - 12/2016
3	Joint Diseases (Joint Disease) 05/2017 - 02/2011
2	COVID-19 03/2022 - 01/2021
2	Cardiovascular Diseases (Cardiovascular Disease) 06/2020 - 01/2020
2	Tyrosinemias (Tyrosinemia) 01/2017 - 04/2016
2	Rheumatic Diseases (Rheumatism) 12/2016 - 11/2016
2	Heart Failure 01/2012 - 01/2011
2	Alkaptonuric ochronosis 12/2011 - 10/2010
2	Stomach Neoplasms (Stomach Cancer) 04/2010 - 05/2009
1	Chronic Pain 06/2023
1	Ischemic Stroke 12/2022
1	Hypoxia (Hypoxemia) 12/2022
1	Brain Ischemia (Cerebral Ischemia) 12/2022
1	Ischemia 12/2022
1	Pain (Aches) 10/2022
1	Peanut Hypersensitivity (Peanut Allergy) 05/2022
1	Lung Diseases (Lung Disease) 01/2021
1	Premature Aging 01/2021
1	Osteoarthritis 12/2020
1	Knee Injuries (Knee Injury) 12/2020
1	Stroke (Strokes) 06/2020
1	Respiratory Tract Diseases (Respiratory Tract Disease) 06/2020
1	Xerostomia 01/2020
1	Atherosclerosis 01/2020
1	Chronic Renal Insufficiency 01/2020
1	Osteoporosis 01/2020
1	Hypertension (High Blood Pressure) 01/2020
1	Rett Syndrome (Rett's Disorder) 03/2019
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 01/2019
1	Renal Insufficiency (Renal Failure) 01/2019
1	Hyperuricemia 01/2019
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 10/2017

Drug/Important Bio-Agent (IBA)

33	Homogentisic AcidIBA 03/2024 - 10/2010
27	Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)IBA 03/2024 - 10/2010
18	EnzymesIBA 01/2023 - 09/2002
14	Proteins (Proteins, Gene)FDA Link 05/2022 - 02/2002
8	Tyrosine (L-Tyrosine)FDA Link 12/2022 - 02/2011
8	Melanins (Melanin)IBA 10/2020 - 10/2010
7	Biomarkers (Surrogate Marker)IBA 12/2022 - 12/2011
6	nitisinone (Orfadin)FDA Link 11/2022 - 02/2016
6	Serum Amyloid A Protein (Serum Amyloid A)IBA 12/2020 - 09/2013
5	Amyloid (Amyloid Fibrils)IBA 02/2017 - 01/2011
4	Phenylalanine (L-Phenylalanine)FDA Link 12/2022 - 12/2011
4	pyrimidineIBA 06/2014 - 11/2007
4	AntioxidantsIBA 09/2013 - 09/2002
3	Blood Proteins (Serum Proteins)IBA 01/2020 - 02/2002
3	src-Family KinasesIBA 11/2017 - 05/2008
3	CytokinesIBA 01/2014 - 09/2002
3	VaccinesIBA 11/2012 - 10/2007
3	AntigensIBA 02/2011 - 10/2007
2	Sulfhydryl Compounds (Thiols)IBA 01/2021 - 12/2011
2	PolymersIBA 01/2019 - 01/2017
2	Congo RedIBA 01/2014 - 11/2012
2	Anti-Bacterial Agents (Antibiotics)IBA 09/2012 - 07/2009
2	Atrial Natriuretic Factor (ANF)IBA 01/2012 - 01/2011
1	CollagenIBA 03/2024
1	Medical MarijuanaIBA 06/2023
1	OzoneIBA 12/2022
1	Morphine (MS Contin)FDA LinkGeneric 10/2022
1	LigandsIBA 03/2022
1	Glycoproteins (Glycoprotein)IBA 01/2022
1	DisulfidesIBA 01/2021
1	Glutathione (Reduced Glutathione)IBA 01/2021
1	Advanced Oxidation Protein Products (AOPP)IBA 12/2020
1	chitotriosidaseIBA 12/2020
1	Oxygen (Dioxygen)IBA 10/2020
1	SmokeIBA 06/2020
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	anethole (trans-anethole)IBA 01/2020
1	Inosine Diphosphate (IDP)IBA 03/2019
1	Intrinsically Disordered ProteinsIBA 03/2019
1	XanthineIBA 01/2019
1	immucillin GIBA 01/2019
1	Allopurinol (Remid)FDA LinkGeneric 01/2019
1	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA 01/2019
1	Uric Acid (Urate)IBA 01/2019
1	Xanthine DehydrogenaseIBA 01/2019
1	HypoxanthineIBA 01/2019
1	Methylnitronitrosoguanidine (MNNG)IBA 12/2018
1	quinone (benzoquinone)IBA 07/2017
1	Acetic Acid (Vinegar)FDA LinkGeneric 07/2017

Therapy/Procedure

9	Therapeutics 06/2023 - 11/2012
4	Precision Medicine 01/2023 - 04/2017
2	Drug Therapy (Chemotherapy) 01/2018 - 11/2017
1	Aftercare (After-Treatment) 10/2022
1	Transplantation 01/2020
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2020